Journal article
The Ovicidal, Larvacidal and Adulticidal Properties of 5,5 '-Dimethyl-2,2 '-Bipyridyl against Drosophila melanogaster
Matthias B Van Hiel, Bert Breugelmans, Charles N Pagel, Adam K Williams, Aiden K Varan, Richard Burke, Vernon M Bowles, Philip Batterham
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2012
Abstract
Insecticide resistance has limited the number of available chemical options for insect pest control. Hence there is a need for new chemistries with novel modes of action. Here we investigate the mode of action for an insecticide that has not yet been released for commercial use. The ovicidal, larvacidal and adulticidal effects of 5,5'-dimethyl -2, 2'-dipyridyl (termed Ha44), which is being developed as a treatment for head lice, were evaluated in the Drosophila melanogaster model system. Ha44 demonstrated significant activity against embryos and was capable of arresting development at a number of stages of embryogenesis. The effects of Ha44 on embryos was shown to be reversible following the..
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Awarded by Linkage Grant from the Australian Research Council
Funding Acknowledgements
This research was supported through a Linkage Grant from the Australian Research Council (Grant LP0884047) and matching support from Hatchtech Pty Ltd. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.