Journal article

Decidua Parietalis-Derived Mesenchymal Stromal Cells Reside in a Vascular Niche Within the Choriodecidua

NM Castrechini, P Murthi, S Qin, GD Kusuma, L Wilton, M Abumaree, S Gronthos, A Zannettino, NM Gude, SP Brennecke, B Kalionis



Mesenchymal stromal cells (MSCs) from gestational tissues represent promising cell populations with stem cell-like properties for use in regenerative medicine. Previously, we reported that MSCs in the chorionic villi of the human placenta reside in a vascular niche. However, the niche(s) in which MSCs reside in the fetal membranes, another rich source of MSCs, remains to be determined. The cell surface markers STRO-1 and 3G5 were previously employed to identify niches in a variety of tissues and here we use these markers to report the location of the MSC niche in the human decidua parietalis. The cultured decidua parietalis MSCs (DPMSCs) isolated from the choriodecidua component of the fetal..

View full abstract


Awarded by National Health and Medical Research Council

Funding Acknowledgements

The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: the National Health and Medical Research Council Grant (grant number 509178); the Royal Women's Hospital Foundation; the Cecilia Kilkeary Foundation; the Eirene Lucas Foundation; the Harold & Cora Brennen Benevolent Trust (Equity Trustees); the Jack Brockhoff Foundation; the J & R McGauran Charitable Trust; the Diana Brown Trust (Perpetual Trustees); the Helen Macpherson Smith Trust; the Thomas R & Rosalinda B Ditchfield Medical Research Endowment Fund and the Wenkart Foundation.