Journal article
Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development
AD Cook, J Pobjoy, S Steidl, M Dürr, EL Braine, AL Turner, DC Lacey, JA Hamilton
Arthritis Research and Therapy | Published : 2012
DOI: 10.1186/ar4037
Abstract
Introduction: Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been shown to be important in the development of inflammatory models of rheumatoid arthritis and there is encouraging data that its blockade may have clinical relevance in patients with rheumatoid arthritis. The aims of the current study were to determine whether GM-CSF may also be important for disease and pain development in a model of osteoarthritis.Methods: The role of GM-CSF was investigated using the collagenase-induced instability model of osteoarthritis. We studied both GM-CSF-/- mice and wild-type (C57BL/6) mice treated prophylactically or therapeutically with a monoclonal antibody to GM-CSF. Disease develop..
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Funding Acknowledgements
We thank Jennifer Davis and Lara Mizhiritsky for assistance with the maintenance and care of the mice, and Amanda J Fosang for the antibody against DIPEN. This work was supported by grants from MorphoSys AG and the National Health and Medical Research Council (NHMRC), and by a NHMRC Senior Principal Research Fellowship (JAH). SS is a full-time employee of MorphoSys AG, Germany. JAH has received consulting fees from MorphoSys AG, Germany (less than $10,000 a year). MD was a full-time employee of MorphoSys AG, Germany, until 2011. MorphoSys AG, Germany, have partially funded the work in this manuscript. Patent applications from the University of Melbourne (ADC, JAH) are pending on the treatment of OA and pain by using GM-CSF antagonists. MorphoSys AG hold patents on anti-GM-CSF antibodies.