Journal article

Loss of APKC expression independently predicts tumor recurrence in superficial bladder cancers

Benjamin Namdarian, Edwin Wong, Ryan Galea, John Pedersen, Xiaowen Chin, Robert Speirs, Patrick O Humbert, Anthony J Costello, Niall M Corcoran, Christopher M Hovens

Urologic Oncology - Seminars and Original Investigations | ELSEVIER SCIENCE INC | Published : 2013


OBJECTIVES: Epithelial-mesenchymal transition (EMT) is known to play an important role in the development of tumor invasion and progression in tumors of epithelial origin. Our aim was to investigate the role of tight junction proteins, Par3/Par6/atypical protein kinase C (APKC), Discs large (Dlg), and Scribble in human bladder pathogenesis. METHODS: We evaluated levels of APKC, Dlg, and Scribble in 92 superficial bladder tumors using tissue microarrays and immunohistochemistry, and correlated expression with pathologic variables and clinical outcomes. RESULTS: There was a slight apparent enrichment in strong vs. weak staining for APKC (54.9% vs. 45.1%), Dlg (65.7% vs. 34.3%), and a marked en..

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