Journal article

Hypometabolism precedes limbic atrophy and spontaneous recurrent seizures in a rat model of TLE

Bianca Jupp, John Williams, David Binns, Rodney J Hicks, Lisa Cardamone, Nigel Jones, Sandra Rees, Terence J O'Brien

EPILEPSIA | WILEY | Published : 2012

Abstract

PURPOSE: Temporal hypometabolism on fluorodeoxyglucose positron emission tomography (FDG-PET) is a common finding in patients with drug-resistant temporal lobe epilepsy (TLE). The pathophysiology underlying the hypometabolism, including whether it reflects a primary epileptogenic process, or whether it occurs later as result of limbic atrophy or as a result of chronic seizures, remains unknown. This study aimed to investigate the ontologic relationship among limbic atrophy, histological changes, and hypometabolism in rats. METHODS: Serial in vivo imaging with FDG-PET and volumetric magnetic resonance imaging (MRI) was acquired before and during the process of limbic epileptogenesis resulting..

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Grants

Awarded by NHMRC


Funding Acknowledgements

The authors wish to thank Milosh Vosmanski, from Austin Health, Heidelberg, Victoria, Australia for the electrodes used in this study and Marnie Collins from the Department of Mathematics and Statistics, The University of Melbourne, for advice regarding the statistical analysis. The study was supported by the Australian Government funded CRC for Biomedical Development and a NHMRC Project Grant to TJ O'Brien and S Rees (#400088).