Journal article

Second to fourth digit ratio (2D: 4D), breast cancer risk factors, and breast cancer risk: a prospective cohort study

DC Muller, L Baglietto, JT Manning, C McLean, JL Hopper, DR English, GG Giles, G Severi



BACKGROUND: We aimed to assess whether 2D:4D measures are associated with breast cancer risk. METHODS: We derived the ratio of the lengths of the index and ring fingers (2D:4D), and right minus left 2D:4D (Δ(r-l)) from digit lengths measured from photocopies of participants' hands collected during a recent follow-up of the Melbourne Collaborative Cohort Study, a prospective study including 24 469 women. Of the 9044 women with available data, we identified 573 incident breast cancer cases. Hazard ratios (HR) and 95% confidence intervals (CI) for a one standard deviation difference in 2D:4D measures were obtained from Weibull survival models, and linear regression models were used to examine p..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was made possible by the contribution of many people, including the original investigators, the Program Manager, and the diligent team who recruited the participants and who continue working on follow-up. We would like to express our gratitude to the many thousands of Melbourne residents who continue to participate in the study. We would like to acknowledge the work of Juliet Anderson, Lily Laskaris, and Judith Heads who measured the vast majority of the digits. This work was supported by grants from the National Health and Medical Research Council (251533, 209057, 504711) and the National Breast Cancer Foundation, and was further supported by infrastructure provided by the Cancer Council Victoria. Cohort recruitment was funded by VicHealth and the Cancer Council Victoria. JLH is a NHMRC Australia Fellow.