Journal article
Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum
WH Tham, J Healer, AF Cowman
Trends in Parasitology | Published : 2012
Abstract
The global agenda for malaria eradication would benefit from development of a highly efficacious vaccine that protects against disease and interrupts transmission of Plasmodium falciparum. It is likely that such a vaccine will be multi-component, with antigens from different stages of the parasite life cycle. In this review, inclusion of blood stage antigens in such a vaccine is discussed. Erythrocyte binding-like (EBL) and P. falciparum reticulocyte binding-like (PfRh) proteins are reviewed with respect to their function in erythrocyte invasion, their role in eliciting antibodies contributing to protective immunity and reduction of invasion, leading subsequently to inhibition of parasite mu..
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Funding Acknowledgements
The research described in this article carried out at the Walter and Eliza Hall Institute of Medical Research was supported by the National Health and Medical Research Council of Australia and made possible through Victorian State Government Operational Infrastructure Support and an Australian Government National Health and Medical Research Council (NHMRC) Independent Research Institute Infrastructure Support Scheme (IRIISS).