Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes
JA Pane, NL Webster, KL Graham, G Holloway, C Zufferey, BS Coulson
DIABETOLOGIA | SPRINGER | Published : 2013
AIMS/HYPOTHESIS: Rotavirus infection in at-risk children correlates with production of serum autoantibodies indicative of type 1 diabetes progression. Oral infection with rhesus monkey rotavirus (RRV) accelerates diabetes onset in mice. This relates to their rotavirus-specific serum antibody titre and local pro-inflammatory cytokine induction without pancreatic infection. Our aim was to further investigate the roles of serum antibodies and viral extra-intestinal spread in diabetes acceleration by rotavirus. METHODS: Rotavirus-specific serum antibody production was detected by ELISA in diabetes-prone mice given either inactivated or low-dose RRV, in relation to their diabetes development. Ser..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was supported by Project Grants (299862 and 509008) and Senior Research Fellowships (350253 and 628319) to B. S. Coulson from the National Health and Medical Research Council of Australia.