Journal article

A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network

MJ Petris, J Camakaris, M Greenough, S LaFontaine, JFB Mercer

HUMAN MOLECULAR GENETICS | OXFORD UNIV PRESS | Published : 1998

Abstract

The human X-linked recessive disorder of copper metabolism, Menkes disease, is caused by a defect in the MNK ( ATP7A ) gene which encodes a transmembrane copper-transporting P-type ATPase (MNK). MNK is an important component of the mammalian copper transport pathway, and previous studies in cultured cells have localized MNK to the final compartment of the Golgi apparatus, the trans -Golgi network (TGN). At this location, MNK is predicted to supply copper to copper-dependent enzymes as they migrate through the secretory pathway. However, under conditions of elevated extracellular copper, the MNK protein undergoes a rapid relocalization to the plasma membrane where it functions in the efflux o..

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University of Melbourne Researchers