Characterisation of antibody responses in pigs induced by recombinant oncosphere antigens from Taenia solium

CM Jayashi; AE Gonzalez; R Castillo Neyra; CT Kyngdon; CG Gauci; MW Lightowlers

Journal article

Characterisation of antibody responses in pigs induced by recombinant oncosphere antigens from Taenia solium

CM Jayashi, AE Gonzalez, R Castillo Neyra, CT Kyngdon, CG Gauci, MW Lightowlers

Vaccine | ELSEVIER SCI LTD | Published : 2012

DOI: 10.1016/j.vaccine.2012.10.057

Abstract

Recombinant antigens cloned from the oncosphere life cycle stage of the cestode parasite Taenia solium (T. solium) have been proven to be effective as vaccines for protecting pigs against infections with T. solium. Previous studies have defined three different host protective oncosphere antigens, TSOL18, TSOL16 and TSOL45. In this study, we evaluated the potential for combining the antigens TSOL16 and TSOL18 as a practical vaccine. Firstly, in a laboratory trial, we compared the immunogenicity of the combined antigens (TSOL16/18) versus the immunogenicity of the antigens separately. Secondly, in a field trial, we tested the ability of the TSOL16/18 vaccine to induce detectable antibody respo..

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University of Melbourne Researchers

Charles Gauci Author

Marshall Lightowlers Author

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Grants

Awarded by Wellcome Trust

Funding Acknowledgements

The authors thank Juan Chanta for his outstanding support during the field studies, the Cysticercosis Working Group in Peru staff in Tumbes, and the staff of the Veterinary Preventive Medicine Laboratory at the Veterinary Faculty of San Marcos University in Lima, for their technical support and assistance. Funding from the Wellcome Trust (grant number GR075818) and the Australian National Health and Medical Research Council (grant numbers 350279, 628320, 100354) is acknowledged.