Journal article

Tissue plasminogen activator does not alter development of acquired epilepsy

Mei-Lyn Tan, Ashley Ng, Puneet S Pandher, Maithili Sashindranath, John A Hamilton, Stephen M Davis, Terence J O'Brien, Robert L Medcalf, Bernard Yan, Nigel C Jones



PURPOSE:   Tissue plasminogen activator (t-PA), a proven therapy for acute ischemic stroke, is an endogenous serine protease associated with neuronal activity and synaptic plasticity in the brain. Its expression is enhanced after seizures, and is involved in seizure propagation throughout the brain. Therefore, the increased use of t-PA to treat stroke may have important implications for the development of poststroke epilepsy. Using experimental and clinical approaches, we investigated the role of t-PA in the development of epilepsy. METHODS:   Mice deficient in t-PA (t-PA(-/-) ) or mice transgenically modified to overexpress neuronal t-PA (T4) underwent amygdala kindling, and seizure thresho..

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