Journal article
The interplay between the effects of lifetime asthma, smoking, and atopy on fixed airflow obstruction in middle age
JL Perret, SC Dharmage, MC Matheson, DP Johns, LC Gurrin, JA Burgess, J Marrone, J Markos, S Morrison, I Feather, PS Thomas, CF McDonald, GG Giles, JL Hopper, R Wood-Baker, MJ Abramson, EH Walters
American Journal of Respiratory and Critical Care Medicine | AMER THORACIC SOC | Published : 2013
Abstract
Rationale: The contribution by asthma to the development of fixed airflow obstruction (AO) and the nature of its effect combined with active smoking and atopy remain unclear. Objectives: To investigate the prevalence and relative influence of lifetime asthma, active smoking, and atopy on fixed AO inmiddle age. Methods: The population-based Tasmanian Longitudinal Health Study cohort born in 1961 (n = 8,583) and studied with prebronchodilator spirometry in 1968 was retraced (n = 7,312) and resurveyed (n = 5,729 responses) from 2002 to 2005. A sample enriched for asthma and chronic bronchitis underwent a further questionnaire, pre- and post-bronchodilator spirometry (n = 1,389), skin prick test..
View full abstractGrants
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
Supported by the National Health and Medical Research Council of Australia grant 299901; Clifford Craig Medical Research Trust of Tasmania; Victorian, Queensland, and Tasmanian Asthma Foundations; and the Australian Lung Foundation.We acknowledge the Tasmanian Longitudinal Health Study (TAHS) participants and previous investigators. We thank Mark Jenkins, Ph.D., Centre for MEGA Epidemiology, Victoria, who is a TAHS investigator but not a coauthor of this manuscript, for his assistance with obtaining funds and data collection. Furthermore, we acknowledge all the respiratory scientists who collected data in the lung function laboratories of Tasmania, Victoria, Queensland, and New South Wales; the research interviewers and data entry operators; and the organizational roles of Ms. Cathryn Wharton and Dr. Desiree Meszaros. The Archives Office of Tasmania provided data from the 1968 and 1974 TAHS questionnaires and copies of the school medical records.