Journal article
Cancer risks for relatives of patients with serrated polyposis
AK Win, RJ Walters, DD Buchanan, MA Jenkins, K Sweet, WL Frankel, A De La Chapelle, DM McKeone, MD Walsh, M Clendenning, SA Pearson, E Pavluk, B Nagler, JL Hopper, MR Gattas, J Goldblatt, J George, GK Suthers, KD Phillips, S Woodall Show all
American Journal of Gastroenterology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2012
DOI: 10.1038/ajg.2012.52
Abstract
OBJECTIVES: Serrated polyposis (hyperplastic polyposis) is characterized by multiple polyps with serrated architecture in the colorectum. Although patients with serrated polyposis are known to be at increased risk of colorectal cancer (CRC) and possibly extracolonic cancers, cancer risk for their relatives has not been widely explored. The aim of this study was to estimate the risks of CRC and extracolonic cancers for relatives of patients with serrated polyposis. METHODS: A cohort of the 1,639 first- and second-degree relatives of 100 index patients with serrated polyposis recruited regardless of a family history of polyps or cancer from genetic clinics in Australia, New Zealand, Canada, an..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by grants from the Cancer Council Queensland, the Hicks Foundation in Victoria, and the National Cancer Institute, National Institutes of Health under 1R01CA123010 (Genetics of Serrated Neoplasia) and RFA # CA-95-011 and through cooperative agreements with the Australasian Colorectal Cancer Family Registry (U01 CA097735). This work was supported in part by the National Cancer Institute (CA67941 and CA16058). J.P.Y is a Cancer Council Queensland Senior Research Fellow. C.R. is the Jass Pathology Fellow (2010-2011). The authors acknowledge the contribution of staff and participants in the Australasian Colorectal Cancer Family Registry, the Genetics of Serrated Neoplasia (GSN) study, the New Zealand Familial Gastrointestinal Cancer Registry, the Ohio State University Medical Center (USA), Familial Gastrointestinal Cancer Registry (Canada), Memorial University of Newfoundland (Canada), and The Jeremy Jass Memorial Pathology Collection. Identification of any relationships that any author or other entity that provided financial or editorial support may have in potential competing interests to those referenced in the submission.