Journal article
Saccadic Eye Movement Characteristics in Adult Niemann-Pick Type C Disease: Relationships with Disease Severity and Brain Structural Measures
LA Abel, EA Bowman, D Velakoulis, MC Fahey, P Desmond, MD Macfarlane, JCL Looi, CL Adamson, M Walterfang
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Abstract
Niemann-Pick Type C disease (NPC) is a rare genetic disorder of lipid metabolism. A parameter related to horizontal saccadic peak velocity was one of the primary outcome measures in the clinical trial assessing miglustat as a treatment for NPC. Neuropathology is widespread in NPC, however, and could be expected to affect other saccadic parameters. We compared horizontal saccadic velocity, latency, gain, antisaccade error percentage and self-paced saccade generation in 9 adult NPC patients to data from 10 age-matched controls. These saccadic measures were correlated with appropriate MRI-derived brain structural measures (e.g., dorsolateral prefrontal cortex, frontal eye fields, supplemental e..
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Funding Acknowledgements
The authors have read the journal's policy and have the following conflicts. Competing interests are as follows: Dr. Abel has served on a scientific advisory board and as a consultant for and received funding for equipment from Actelion Pharmaceuticals Ltd. Ms. Bowman reports no competing interests. Dr. Velakoulis conceived the study, assisted with neuroimaging analysis, contributed to study design and edited the manuscript. He has received royalties from the publication of Kaplan and Sadock's Comprehensive Textbook of Psychiatry (Lippincott Williams & Wilkins, 2009) and receives research support from NH&MRC. Dr. Fahey has served on a scientific advisory board and as a consultant for and received funding for travel from Actelion Pharmaceuticals Ltd; has received speaker honoraria from the Australian Podiatry Association; receives research support from NH&MRC and the NIH (1R03HD058625-01, CI); has held/holds stock in Sigma Pharmaceuticals, Ltd and Peplin, Inc.; and has given expert testimony on behalf of the Therapeutic Goods Administration. Dr. Desmond serves on the editorial board of the Journal of Clinical Neuroscience and as an Associate Editor of the Journal of Medical Imaging and Radiation Oncology; and receives research support from NHMRC, Cancer Australia, the National Health Foundation, and The Royal Melbourne Hospital Neuroscience Foundation. Dr. Macfarlane, Dr. Looi and Dr. Adamson report no competing interests. Dr. Walterfang has served on a scientific advisory board and as a consultant for and received funding for travel from Actelion Pharmaceuticals Ltd; and received royalties from the publication of Kaplan and Sadock's Comprehensive Textbook of Psychiatry (Lippincott Williams & Wilkins, 2009). This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.