Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity

Victoria Lewis; Cathryn L Haigh; Colin L Masters; Andrew F Hill; Victoria A Lawson; Steven J Collins

Journal article

Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity

Victoria Lewis, Cathryn L Haigh, Colin L Masters, Andrew F Hill, Victoria A Lawson, Steven J Collins

MOLECULAR NEURODEGENERATION | BMC | Published : 2012

DOI: 10.1186/1750-1326-7-18

University of Melbourne Researchers

Steven Collins Author Medicine - Royal Melbourne Hospital

Colin Masters Author Florey Department of Neuroscience and Mental Health

Vicki Lawson Author Microbiology and Immunology

Vicki Lewis Author Medicine - Royal Melbourne Hospital

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Prion protein cleavage.

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Grants

Awarded by Australian Government National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Awarded by Australian Research Council

Funding Acknowledgements

The authors thank Professor Charles Weissmann for the gift of the Tga20 transgenic mice, the Animal Housing Facility staff in the Faculty of Medicine, Dentistry and Health Sciences, the University of Melbourne for their assistance with animal husbandry, and Ms Laura Leone for technical assistance with preparation of the mouse brains for neuropathological assessment. This work was funded by an Australian Government National Health and Medical Research Council (NHMRC) Program Grant (#400202). VL is supported by NHMRC Training Fellowship (#567123). SJC is supported by NHMRC Practitioner Fellowship (#400183). VAL is supported by The University of Melbourne CR Roper Fellowship. AFH is supported by an Australian Research Council Future Fellowship (FT10100560).