Therapeutic targeting of the complement system in age-related macular degeneration: a review
Robyn Troutbeck, Salmaan Al-Qureshi, Robyn H Guymer
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | WILEY | Published : 2012
The last decade has produced pivotal change in our understanding of the molecular mechanisms underlying age-related macular degeneration (AMD), a leading cause of global blindness. In this time, the complement system has featured as a unifying theme for several elements of new evidence: initially, the discovery of complement proteins within drusen and subsequently, the association between AMD and mutations in various complement pathway genes, most notably complement factor H. Increasingly, a wealth of data are pointing towards a role for chronic local inflammation and complement activation in the patho-aetiology of AMD. These findings have paved the way for the exploration of a new paradigm ..View full abstract
Awarded by NHMRC Centre for Clinical Research Excellence
RT is supported by a retinal fellowship from Novartis Australia, and RHG is supported by a National Health and Medical Research Council (NHMRC) practitioner fellowship (RHG). CERA receives Operational Infrastructure Support from the Victorian Government and is also supported by an NHMRC Centre for Clinical Research Excellence #529923 award.