Journal article

Endogenous parathyroid hormone is associated with reduced cartilage volume in vivo in a population-based sample of adult women

Sharon Lee Brennan, Flavia M Cicuttini, Geoff C Nicholson, Julie A Pasco, Mark A Kotowicz, Anita Wluka

ANNALS OF THE RHEUMATIC DISEASES | BMJ PUBLISHING GROUP | Published : 2012

Abstract

OBJECTIVES: Animal and in vitro studies suggest that parathyroid hormone (PTH) may affect articular cartilage. However, little is known of the relationship between PTH and human joints in vivo. DESIGN: Longitudinal. SETTING: Barwon Statistical Division, Victoria, Australia. PARTICIPANTS: 101 asymptomatic women aged 35-49 years (2007-2009) and without clinical knee osteoarthritis, selected from the population-based Geelong Osteoporosis Study. RISK FACTORS: Blood samples obtained 10 years before (1994-1997) and stored at -80°C for random batch analyses. Serum intact PTH was quantified by chemiluminescent enzyme assay. Serum 25-hydroxyvitamin D (25(OH)D) was assayed using equilibrium radioimmun..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by NHMRC


Funding Acknowledgements

The National Health and Medical Research Council (NHMRC) of Australia (251638 and 436665), the Victorian Health Promotion Foundation, the LEW Carty Foundation and Arthritis Australia supported this study. SLB was the recipient of an NHMRC Early Career Fellowship (1012472), and AEW was the recipient of an NHMRC Career Development Award (545876).