Remote Ischemic Preconditioning (RIPC) Modifies Plasma Proteome in Humans
Michele Hepponstall, Vera Ignjatovic, Steve Binos, Paul Monagle, Bryn Jones, Michael HH Cheung, Yves d'Udekem, Igor E Konstantinov
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2012
Remote Ischemic Preconditioning (RIPC) induced by brief episodes of ischemia of the limb protects against multi-organ damage by ischemia-reperfusion (IR). Although it has been demonstrated that RIPC affects gene expression, the proteomic response to RIPC has not been determined. This study aimed to examine RIPC induced changes in the plasma proteome. Five healthy adult volunteers had 4 cycles of 5 min ischemia alternating with 5 min reperfusion of the forearm. Blood samples were taken from the ipsilateral arm prior to first ischaemia, immediately after each episode of ischemia as well as, at 15 min and 24 h after the last episode of ischemia. Plasma samples from five individuals were analyse..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
This project was funded by the National Health and Medical Research Council (NHMRC) grant (# 628756) and NHMRC postgraduate scholarship (# 1017734). Yves d'Udekem is a Career Development Fellow of The National Heart Foundation of Australia (CR 10M 5339). This study was supported by the Victorian Government's Operational Infrastructure Support Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.