Journal article
Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-β: Prodromal Alzheimer's disease?
YY Lim, KA Ellis, K Harrington, RH Pietrzak, J Gale, D Ames, AI Bush, D Darby, RN Martins, CL Masters, CC Rowe, G Savage, C Szoeke, VL Villemagne, P Maruff
Journal of Alzheimer S Disease | IOS PRESS | Published : 2013
DOI: 10.3233/JAD-121771
Abstract
We aimed to characterize the nature and magnitude of cognitive decline in a group of adults with amnestic mild cognitive impairment (aMCI) with high and low levels of amyloid-β (Aβ) in relation to healthy older adults with low Aβ levels. Healthy older adults and adults with aMCI enrolled in the Australian Imaging, Biomarker, and Lifestyle study, completed the CogState brief battery at baseline and 18 months, and underwent positron emission tomography neuroimaging for Aβ at baseline. In this study, we included adults with MCI who had been classified as having high and low levels of Aβ and healthy older adults who had been classified as having low levels of Aβ. Linear model analyses adjusted f..
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Funding Acknowledgements
Funding for the study was provided in part by the study partners: Australian Commonwealth Scientific Industrial and Research Organization, Edith Cowan University, Mental Health Research institute, Alzheimer's Australia, National Ageing Research Institute, Austin Health, CogState Ltd., Hollywood Private Hospital, Sir Charles Gardner Hospital. The study also received support from the National Health and Medical Research Council and the Dementia Collaborative Research Centres program, as well as ongoing funding from the Science and Industry Endowment Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.