Journal article
Rapid decline in episodic memory in healthy older adults with high amyloid-β
YY Lim, RH Pietrzak, KA Ellis, J Jaeger, K Harrington, T Ashwood, C Szoeke, RN Martins, AI Bush, CL Masters, CC Rowe, VL Villemagne, D Ames, D Darby, P Maruff
Journal of Alzheimer S Disease | IOS PRESS | Published : 2013
Abstract
High levels of amyloid-β (Aβ) have been associated with greater rates of decline in episodic memory over 18 months in healthy older adults. Serial assessments over shorter time intervals may facilitate earlier detection of Aβ-related memory decline in healthy older adults. In forty-four healthy older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Rate of Change Sub-Study, we compared rates of change in cognition over six months in healthy older adults with high and low levels of Aβ. High Aβ was associated with greater decline in episodic memory measures over 6 months in healthy older adults. © 2013 - IOS Press and the authors. All rights reserved.
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Funding Acknowledgements
Funding for the study was provided by AstraZeneca Pharmaceuticals LP, and in part by the study partners (Australian Commonwealth Scientific Industrial and Research Organization, Edith Cowan University, Mental Health Research Institute, Alzheimer's Australia, National Ageing Research Institute, Austin Health, CogState Ltd., Hollywood Private Hospital, and Sir Charles Gardner Hospital. The study also received support from the National Health and Medical Research Council, the Dementia Collaborative Research Centres program, and the McCusker Alzheimer's Research Foundation, Inc., as well as ongoing funding from the Science and Industry Endowment Fund.