Journal article

Regulation of glycogen synthase kinase-3 beta (GSK-3 beta) by the Ala pathway in gliomas

Ryan J Atkins, James Dimou, Lucy Paradiso, Andrew P Morokoff, Andrew H Kaye, Katharine J Drummond, Christopher M Hovens

JOURNAL OF CLINICAL NEUROSCIENCE | ELSEVIER SCI LTD | Published : 2012

Abstract

Gliomas are aggressive brain tumours that, despite advances in multimodal therapies, continue to portend a dismal prognosis. Glioblastoma multiforme (GBM) represents the most aggressive glioma and patients have a median survival of 14 months, even with the best available treatments. The phosphoinositide 3-kinase/Akt/glycogen synthase kinase-3 beta (GSK-3β) and Wnt/β-catenin pathways are dysregulated in a number of cancers, and these two pathways share a common node protein, GSK-3β. This protein is responsible for the regulation/degradation of β-catenin, which reduces β-catenin's translocation to the nucleus and influences the subsequent transcription of oncogenes. The non-specific small-mole..

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