Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/beta-catenin signalling thresholds for tumourigenesis
M Christie, RN Jorissen, D Mouradov, A Sakthianandeswaren, S Li, F Day, C Tsui, L Lipton, J Desai, IT Jones, S McLaughlin, RL Ward, NJ Hawkins, AR Ruszkiewicz, J Moore, AW Burgess, D Busam, Q Zhao, RL Strausberg, AJ Simpson Show all
Oncogene | NATURE PUBLISHING GROUP | Published : 2013
Awarded by NHMRC
Awarded by Cancer Research UK
This work was supported by the CSIRO Preventative Health Flagship through an Australian Cancer Grid Project Grant (to LL, PG and OMS), the NHMRC through a Project Grant (Application ID 489418; to LL, OMS, PG and RLW) and a Program Grant (Application ID 487922; to AWB), the Hilton Ludwig Cancer Metastasis Initiative (to LL, PG and OMS) and the Victorian Government through a Victorian Cancer Agency Translation Cancer Research Grant (to LL, PG and OMS). This work was supported by funds from the Operational Infrastructure Support Program provided by the Victorian Government, Australia. MC and FD are supported by the Cancer Council Victoria through Postgraduate Cancer Research Scholarships and LL by the CSIRO Preventative Health Flagship through a Clinical Researcher Fellowship. We thank the Victorian Cancer Biobank for the provision of patient specimens, BioGrid Australia for providing de-identified clinical data.