Journal article
Diffusion tensor imaging of acute inflammatory lesion evolution in multiple sclerosis
Y Liu, PJ Mitchell, TJ Kilpatrick, MS Stein, LC Harrison, J Baker, M Ditchfield, K Li, GF Egan, H Butzkueven, SC Kolbe
Journal of Clinical Neuroscience | ELSEVIER SCI LTD | Published : 2012
Abstract
The initiating events in multiple sclerosis (MS) plaque formation are poorly understood. Retrospective analysis of serial imaging data can improve the understanding of tissue changes characterising acute MS lesion evolution. This study aimed to assess lesion evolution using diffusion tensor imaging data from serially acquired scans from 22 patients with MS. Mean diffusivity (MD) and fractional anisotropy (FA) were measured from 13 suitable plaques from five patients and carefully matched regions of contralateral normal-appearing white matter. Measurement times were on average: 5 months and 1 month prior to, during, and 1 month and 2 months post gadolinium-enhancement. A significant increase ..
View full abstractGrants
Awarded by Multiple Sclerosis Trust
Funding Acknowledgements
This work was generously supported by philanthropic funding from the Myer Foundation as well as the McDonald Fellowship from the Multiple Sclerosis International Federation (MSIF) and the National Science Foundation of China (Nos 81101038, 30930029) (Y. Liu), the Australian National Health and Medical Research Council (NHMRC) Principal Research Fellowship (Grant 400317, G. F. Egan), Australia, the joint MS Research Australia/Trish MS Foundation/NHMRC Betty Cuthbert Fellowship (Grant 400476, H. Butzkueven), the joint MS Research Australia/Australian Financial Advisors Association Postgraduate Scholarship (S. Kolbe), Charityworks for MS, Melbourne, and the Neurosciences Victoria Neuro-informatics Platform. We thank Ms Gabrielle Browning for assisting with coordinating the study, the MR imaging technical team at the Royal Children's Hospital for assisting with MR data collection, and all the participants in the study.