Journal article
Retinal microvascular calibre and risk of incident diabetes: The multi-ethnic study of atherosclerosis
JWY Yau, J Xie, E Lamoureux, R Klein, BEK Klein, MF Cotch, AG Bertoni, S Shea, TY Wong
Diabetes Research and Clinical Practice | ELSEVIER IRELAND LTD | Published : 2012
Abstract
Aim: To prospectively examine the association of retinal microvascular signs with incident diabetes and impaired fasting glucose (IFG) in a multi-ethnic population-based cohort. Methods: The multi-ethnic study of atherosclerosis comprised Caucasians, African-Americans, Hispanics and Chinese aged 45-84. years. Retinal vascular calibre and retinopathy were quantified from baseline retinal photographs. Incident diabetes and IFG were ascertained prospectively. Results: After a median follow-up of 3. years, 243 (4.9%) people developed diabetes and 565 (15.0%) developed IFG. After adjusting for known risk factors, participants with wider retinal arteriolar calibre had a higher risk of developing d..
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Awarded by National Institutes of Health
Funding Acknowledgements
This research was supported by contracts N01-HC-95159 through N01-HC-95165 and N01-HC-95169 from the National Heart, Lung, and Blood Institute and NIH Intramural Research award Z01EY000403 from the National Eye Institute (MFC). Additional support was provided by National Institutes of Health grants HL69979-03 (Klein R. and Wong T.Y.) and the National Health and Medical Research Council (NHMRC), 52993, Australia (Wong T.Y.).