Journal article

Fibroid-Associated Heavy Menstrual Bleeding: Correlation Between Clinical Features, Doppler Ultrasound Assessment of Vasculature, and Tissue Gene Expression Profiles

Sophia E Tsiligiannis, Marina Zaitseva, Peter R Coombs, Paul Shekleton, Moshe Olshansky, Martha Hickey, Beverley Vollenhoven, Peter AW Rogers

REPRODUCTIVE SCIENCES | SAGE PUBLICATIONS INC | Published : 2013

Abstract

Despite the prevalence of uterine fibroids (Fs), few studies have investigated the links between clinical features and the cellular or molecular mechanisms that drive F growth and development. Such knowledge will ultimately help to differentiate symptomatic from asymptomatic Fs and could result in the development of more effective and individualized treatments. The aim of this study was to investigate the relationship between ultrasound appearance, blood flow, and angiogenic gene expression in F, perifibroid (PM), and distant myometrial (DM) tissues. We hypothesized that angiogenic gene expression would be increased in tissues and participants that showed increased blood flow by Doppler ultr..

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