Journal article

Engineering Cellular Degradation of Multilayered Capsules through Controlled Cross-Linking

Kang Liang, Georgina K Such, Zhiyuan Zhu, Sarah J Dodds, Angus PR Johnston, Jiwei Cui, Hirotaka Ejima, Frank Caruso

ACS NANO | AMER CHEMICAL SOC | Published : 2012


We report a versatile approach for controlling the intracellular degradation of polymer capsules by tailoring the degree of cross-linking in the capsules. Poly(2-diisopropylaminoethyl methacrylate) capsules were assembled by the layer-by-layer technique and covalently stabilized with a redox-responsive bisazide cross-linker using click chemistry. The degree of cross-linking, determined using radiation scintillation counting, was tuned from 65% to 98% by adjusting the amount of cross-linker used to stabilize the polymer films. Transmission electron microscopy and fluorescence microscopy studies showed that the pH responsiveness of the capsules was maintained, regardless of the degree of cross..

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