Journal article
Decreased expression of complement 3a receptor (C3aR) in human placentas from severe preeclamptic pregnancies
R Lim, M Lappas
European Journal of Obstetrics and Gynecology and Reproductive Biology | ELSEVIER SCIENCE BV | Published : 2012
Abstract
Objectives: The aim of this study was to determine the expression of the anaphylatoxin receptors complement C3a receptor (C3aR) and C5a receptor (C5aR) in the placentas of pregnancies complicated by severe early onset preeclampsia. Study design: We recruited women with pregnancies complicated by severe early-onset preeclampsia (n = 19, 11 of which were further complicated with IUGR) and women with preterm pregnancies not affected by preeclampsia (n = 8). Gene and protein expression of C3aR and C5aR was analysed by quantitative RT-PCR and Western blotting, respectively. Results: C3aR was detected in the Hofbauer cells in the villous stroma of the placenta. C5aR staining was detected in the sy..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
Dr Martha Lappas was a recipient of a National Health and Medical Research Council (NHMRC) RD Wright Fellowship (grant no. 454777). The work described in this manuscript was funded by a project grant from the NHMRC (grant no. 454310). Funding for ChemiDoc XRS and xMark Microplate Absorbance Spectrophotometer was provided by the Medical Research Foundation for Women and Babies.