Journal article

MURINE CYTOMEGALOVIRUS INTERACTS WITH MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULES TO ESTABLISH CELLULAR INFECTION

MN WYKES, GR SHELLAM, J MCCLUSKEY, WM KAST, PB DALLAS, P PRICE

Journal of Virology | AMER SOC MICROBIOLOGY | Published : 1993

Abstract

The expression of stable, correctly folded major histocompatibility complex class I molecules conferred susceptibility to murine cytomegalovirus (MCMV) in cells which were previously resistant to infection, demonstrating that these molecules interact critically with MCMV to initiate infection. All class I molecules could potentiate MCMV infection but H-2Dd and Kb molecules were most efficient. Monoclonal antibodies specific for the alpha 1 and/or alpha 2 domains of Dd and Kb inhibited infection. Infection of L cells transfected with hybrid major histocompatibility complex class I molecules demonstrated that allelic control of susceptibility to MCMV mapped to the alpha 1 domain of Dd when in ..

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University of Melbourne Researchers