Journal article
An anti-inflammatory role for leukemia inhibitory factor receptor signaling in regenerating skeletal muscle
LC Hunt, A Upadhyay, JA Jazayeri, EM Tudor, JD White
Histochemistry and Cell Biology | SPRINGER | Published : 2013
Abstract
Skeletal muscle regeneration in pathology and following injury requires the coordinated actions of inflammatory cells and myogenic cells to remove damaged tissue and rebuild syncytial muscle cells, respectively. Following contusion injury to muscle, the cytokine leukemia inhibitor factor (LIF) is up-regulated and knockout of Lif negatively impacts on morphometric parameters of muscle regeneration. Although it was speculated that LIF regulates muscle regeneration through direct effects on myogenic cells, the inflammatory effects of LIF have not been examined in regenerating skeletal muscle. Therefore, the expression and function of LIF was examined using the antagonist MH35-BD during specific..
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Funding Acknowledgements
The authors acknowledge the contributions of Kitipong Uaesoontrachoon and Charles Pagel for providing oligonucleotide primer sequences for the genes Myod1 and Myog. Su Toulson should also be acknowledged for her contributions toward the sampling of mice and subsequent processing of those samples. This work was funded by the Muscular Dystrophy Association of Australia (MDA) and supported by the Victorian Government's Operational Infrastructure Support Program.