Journal article
The mGlu5 receptor antagonist MTEP attenuates opiate self-administration and cue-induced opiate-seeking behaviour in mice
RM Brown, MR Stagnitti, JR Duncan, AJ Lawrence
Drug and Alcohol Dependence | ELSEVIER IRELAND LTD | Published : 2012
Abstract
The mGlu5 receptor (mGluR5) has been implicated in the rewarding effect of various drugs of abuse and drug-seeking behaviour. In the present study we investigated the impact of antagonism of mGluR5 with the selective negative allosteric, modulator 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) on operant self-administration of morphine as well as cue-induced drug-seeking in adult CD1 mice. Administration of MTEP (20. mg/kg, i.p.) attenuated operant responding for morphine (0.1. mg/kg/infusion) and cue-induced morphine-seeking after a period of forced abstinence. Collectively, these data implicate mGluR5 in the reinforcing effects of opiates and support the proposition that mGluR5 is a..
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Awarded by State Government of Victoria
Funding Acknowledgements
These studies were supported by the National Health & Medical Research Council of Australia (project grant 566736) of which AJL is a Principal Research Fellow and RMB is an Early Career Research Fellow. Financial support from the Pratt/Besen Foundations is also gratefully acknowledged. This work was also supported by the Victorian Government's Operational Infrastructure Support Program.