Journal article
Isoflurane induces cognitive deficits in the Morris water maze task in rats
JK Callaway, NC Jones, CF Royse
European Journal of Anaesthesiology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2012
Abstract
Background: Postoperative cognitive dysfunction has been reported in young, middle-aged and elderly patients with greater incidence with increasing age. Neurocognitive deficits are associated with anaesthetic exposure in aged rodents but in younger adult animals the findings are inconsistent and in middle-aged animals they are unknown. We aimed to compare the effects of moderate duration isoflurane anaesthesia in 100% oxygen on Morris water maze performance in young adult and middle-aged rats. We hypothesised that isoflurane would have greater effects on learning and memory in middle-aged compared with young rats. Materials and methods: Young adult (3 months, n=25) and middle-aged (12 months..
View full abstractGrants
Awarded by National Heart Foundation, Australia
Funding Acknowledgements
[ "This work was supported by the National Heart Foundation, Australia (grant number 809274).", "None for J.K.C. or N.C.J. C.F.R. has received funding for clinical studies, travel and consultancy from Baxter Healthcare which is an organisation that could have an interest in the drug being studied." ]