Journal article

Pathological Changes in the White Matter after Spinal Contusion Injury in the Rat

C Joakim Ek, Mark D Habgood, Ross Dennis, Katarzyna M Dziegielewska, Carina Mallard, Benjamin Wheaton, Norman R Saunders

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2012

Abstract

It has been shown previously that after spinal cord injury, the loss of grey matter is relatively faster than loss of white matter suggesting interventions to save white matter tracts offer better therapeutic possibilities. Loss of white matter in and around the injury site is believed to be the main underlying cause for the subsequent loss of neurological functions. In this study we used a series of techniques, including estimations of the number of axons with pathology, immunohistochemistry and mapping of distribution of pathological axons, to better understand the temporal and spatial pathological events in white matter following contusion injury to the rat spinal cord. There was an initi..

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