Journal article
Association of hypomagnesemia with inferior survival in a phase III, randomized study of cetuximab plus best supportive care versus best supportive care alone: NCIC CTG/AGITG CO.17
MM Vickers, CS Karapetis, D Tu, CJ O'Callaghan, TJ Price, NC Tebbutt, G Van Hazel, JD Shapiro, N Pavlakis, P Gibbs, J Blondal, U Lee, JM Meharchand, RL Burkes, SH Rubin, J Simes, JR Zalcberg, MJ Moore, L Zhu, DJ Jonker
Annals of Oncology | Published : 2013
Abstract
Background: Cetuximab-induced hypomagnesemia has been associated with improved clinical outcomes in advanced colorectal cancer (CRC). We explored this relationship from a randomized clinical trial of cetuximab plus best supportive care (BSC) versus BSC alone in patients with pretreated advanced CRC. Patients and methods: Day 28 hypomagnesemia grade (0 versus ≥1) and percent reduction (<20% versus ≥20%) of Mg from baseline was correlated with outcome. Results: The median percentage Mg reduction at day 28 was 10% (-42.4% to 63.0%) for cetuximab (N = 260) versus 0% (-21.1% to 25%) for BSC (N = 251) [P < 0.0001]. Grade ≥1 hypomagnesemia and ≥20% reduction from baseline at day 28 were associated ..
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Funding Acknowledgements
CSP Consultancy (Amgen, Astra Zeneca, Merck, Roche), Honoraria (Merck); TJP Consultancy (Merck); NCT Consultancy (Merck Serono), Research funding (Merck Serono); GVH Consultancy (Amgen, Merck Serono, Roche), Research funding (Merck Serono); JDS Consultancy (Merck); NO Consultancy (Merck) and Honoraria (Merck); PH Consultancy (Merck Serono); JS Research funding (Bristol-Myers Squibb); JRZ Research funding (Amgen, Merck Serono), DJJ Consultancy (Amgen, Bristol-Myers Squibb), Honoraria (Amgen, Bristol-Myers Squibb). The following authors have declared no conflicts of interest: MMV, DT, CJO, JBl, JMM, RLB, SHR, MJM, and LZ.