Journal article

EFFECT OF TUMOR-NECROSIS-FACTOR ON THE ANTITUMOR EFFICACY AND TOXICITY OF AMINOPTERIN-MONOCLONAL ANTIBODY CONJUGATES - PARAMETERS FOR OPTIMIZATION OF THERAPY

SM RUSSELL, KG KRAUER, IFC MCKENZIE, GA PIETERSZ

CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 1990

Abstract

Immunoconjugates of monoclonal antibodies with drugs, isotopes, or toxins are currently being investigated for their therapeutic effect on tumors. However, all have problems of access of the immunoconjugate to the tumor, particularly with solid tumors. To address this problem, we have used aminopterin-monoclonal antibody (AMN-mAb) conjugates combines with murine tumor necrosis factor (mTNF-alpha), which is known to have specific effects on tumor vasculature. In a murine model, well-established tumors (measuring 1.0-1.4 cm in diameter) were either totally eradicated or considerably reduced in size with combined therapy--a greater effect than with either mTNF-alpha or AMN-mAb used alone. The m..

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