Journal article
Genetic association of refractive error and axial length with 15q14 but not 15q25 in the blue mountains eye study cohort
M Schache, AJ Richardson, P Mitchell, JJ Wang, E Rochtchina, AC Viswanathan, TY Wong, SM Saw, F Topouzis, J Xie, X Sim, EG Holliday, J Attia, RJ Scott, PN Baird
Ophthalmology | ELSEVIER SCIENCE INC | Published : 2013
Abstract
Purpose: Myopia is a common complex condition influenced by genetic and environmental factors. Two recent genome-wide association studies have identified loci on chromosomes 15q25 and 15q14 associated with refractive error in Caucasian populations. Our study aimed to assess the association of these 2 loci with refractive error and ocular biometric measures in an independent ethnically matched Caucasian cohort. Design: Genetic association study using unrelated individuals. Participants: Blue Mountains Eye Study (BMES) cohort. A total of 1571 individuals were included in this study. Methods: Single nucleotide polymorphism (SNP) genotype data were collected from the BMES cohort as part of the W..
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Awarded by Medical Research Council
Funding Acknowledgements
National Health and Medical Research Council, Canberra, Australia (Project Grants: 974159, 211069, 457349, 512423, 475604, and 529912); Centre for Clinical Research Excellence in Translational Clinical Research in Eye Diseases; National Health & Medical Research Council research fellowships to P.N.B. (No. 1028444) and J.J.W. (No. 358702, 632909); Wellcome Trust as part of the Wellcome Trust Case Control Consortium 2 (No. 085475B08Z, 08547508Z, 076113); Medical Research Council (UK) (G0401527); Fight for Sight (London); and National Institute for Health Research grant for a Biomedical Research Centre for Ophthalmology. This study used genotyping data generated and funded by the Wellcome Trust Case-Control Consortium 2 using samples from the BMES.