Journal article
Retinal arteriolar tortuosity is associated with retinopathy and early kidney dysfunction in type 1 diabetes
MB Sasongko, TY Wong, KC Donaghue, N Cheung, AJ Jenkins, P Benitez-Aguirre, JJ Wang
American Journal of Ophthalmology | ELSEVIER SCIENCE INC | Published : 2012
Abstract
To examine the association of retinal vessel tortuosity with diabetic retinopathy and early nephropathy in type 1 diabetes. Cross-sectional. A total of 1159 participants with type 1 diabetes aged 12 to 20 years, attending diabetes clinics in Children's Hospital at Westmead, Sydney, Australia between 1990 and 2002, were included. Retinal photography and clinical examinations were performed during the baseline visit to assess diabetic retinopathy and albumin excretion rate (AER). Retinal vessel tortuosity was measured from digitized retinal photographs using a semi-automated computer program by a single grader masked to participants' characteristics. Diabetic retinopathy was defined as ETDRS l..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
THE CENTRE FOR EYE RESEARCH AUSTRALIA, RECEIVES OPERATIONAL INFRASTRUCTURE SUPPORT FROM THE VICTORIAN government. This study is supported by the National Health and Medical Research Council Grant (NHMRC) 475605 (T.Y.W., KG., A.J.), Australia; the Juvenile Diabetes Research Foundation (JDRF) Innovative Grant (T.Y.W., K.D., A.J., N.C.), Australia; the Royal Victorian Eye and Ear Hospital (RVEEH) Research Grant (N.C.), Australia; NHMRC 529923, National Medical Research Council (NMRC), NMRC/STaR/0003/2008 Singapore, NMRC IRG07nov013 Singapore, and Singapore Bio Imaging Consortium (SBIC) Grant C-011/2006 Singapore. None of the authors had any conflict of interest, and the funding organizations had no role in the design or conduct of this research. Involved in design of study, conduct of study, and collection and management of data (M.B.S., N.C., K.C.D., T.Y.W., J.J.W.); statistical analyses (M.B.S.); interpretation of data (M.B.S., T.Y.W., J.J.W.); preparation of manuscript (M.B.S.); critical review, editing, and approval of the manuscript (M.B.S., T.Y.W., K.C.D., N.C., A.J.J., P.B., J.J.W.). This study followed the principles of the Declaration of Helsinki, with ethics approval obtained from the Children's Hospital at Westmead Ethics Committee. Written consent was obtained from each participant.