Modulation of Conotoxin Structure and Function Is Achieved through a Multienzyme Complex in the Venom Glands of Cone Snails

Helena Safavi-Hemami; Dhana G Gorasia; Andrew M Steiner; Nicholas A Williamson; John A Karas; Joanna Gajewiak; Baldomero M Olivera; Grzegorz Bulaj; Anthony W Purcell

Journal article

Modulation of Conotoxin Structure and Function Is Achieved through a Multienzyme Complex in the Venom Glands of Cone Snails

Helena Safavi-Hemami, Dhana G Gorasia, Andrew M Steiner, Nicholas A Williamson, John A Karas, Joanna Gajewiak, Baldomero M Olivera, Grzegorz Bulaj, Anthony W Purcell

Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2012

DOI: 10.1074/jbc.M112.366781

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University of Melbourne Researchers

Nicholas Williamson Author Bio21 Institute

John Karas Author Chemistry

Dhana Gorasia Author Melbourne Dental School

Related Projects (1)

Biosynthesis, folding and modification of conotoxins

Disulfide-rich peptides represent a diverse family of bioactive molecules which have been developed as drugs for the treatment of severe pai..

Grants

Awarded by National Institutes of Health, NIGMS

Awarded by Australian Research Council

Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

Funding Acknowledgements

This work was supported, in whole or in part, by National Institutes of Health, NIGMS, Program Project GM48677. This work was also supported by Australian Research Council Grant DP110101331.