Journal article
Different changes in cortical tumor necrosis factor-α-related pathways in schizophrenia and mood disorders
B Dean, AS Gibbons, N Tawadros, L Brooks, IP Everall, E Scarr
Molecular Psychiatry | Published : 2013
DOI: 10.1038/mp.2012.95
Abstract
The growing body of evidence implicating tumor necrosis factor-α (TNFα) in the pathophysiology of psychiatric disorders led us to measure levels of that protein in the cortex of subjects with major depressive disorders (MDD). Having reported an increase (458%) in the levels of the transmembrane (tmTNFα), but not the soluble (sTNFα), form of the protein in Brodmann's area (BA) 46, but not 24, in people with the disorder, we decided to examine additional components of TNFα-related pathways in the same regions in people with MDD and extend our studies to the same cortical regions of people with schizophrenia (Sz) and bipolar disorders (BD). Using postmortem tissue, western blots and quantitativ..
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Funding Acknowledgements
BD is an NHMRC Senior Research Fellow and ES is an ARC Future Fellow. This work was supported in part by grants-in-aid from the Rebecca Cooper Medical Research Foundation and the Victorian Government's Operational Infrastructure Support program. Financial support for the experiments described in this paper was from the National Health and Medical Research Council, Australian Research Council, The State Government of Victoria (infrastructure) and The Rebecca L Cooper Medical Research Foundation.