Journal article
Assessment of the Association of Matrix Metalloproteinases with Myopia, Refractive Error and Ocular Biometric Measures in an Australian Cohort
M Schache, PN Baird
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Open access
Abstract
Extracellular matrix proteins have been implicated in protein remodelling of the sclera in refractive error. The matrix metalloproteinases (MMPs) falling into the collagenase (MMP1, MMP8, MMP13), gelatinase (MMP2, MMP9) and stromelysin (MMP3, MMP10, MMP11) functional groups are particularly important. We wished to assess their association with myopia, refractive error and ocular biometric measures in an Australian cohort. A total of 543 unrelated individuals of Caucasian ethnicity were genotyped including 269 myopes (≤-1.0D) and 274 controls (>-1.0D). Tag single nucleotide polymorphisms (SNPs) (n = 53) were chosen to encompass these eight MMPs. Association tests were performed using linear a..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
Funding for this work came from the National Health and Medical Research Council (NHMRC) Canberra, Australia through the Centre for Clinical Research Excellence in Translational Clinical Research in Eye Diseases (grant no.: 529923) and an NHMRC research fellowship to PNB (No. 1028444). The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.