Is BID required for NOD signalling?

Abstract

Arising from G. Yeretssian et al.10.1038/nature09982.Innate immune signalling mediated by the nucleotide-binding and oligomerization domain (NOD) receptors for pathogen-associated constituents regulates the response to intracellular peptidoglycans present in Gram-negative and Gram-positive bacteria. Recently, Yeretssian et al.1 reported that the pro-apoptotic BH3-only BCL2 family member BID is essential for NOD-mediated immune signalling. This was on the basis of their finding that bone marrow-derived macrophages (BMDMs) from Bid−/− mice failed to activate NF-κB and extracellular signal-regulated kinase (ERK), and were unable to secrete inflammatory cytokines after stimulation with NOD ligan..