Journal article

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

Rune Busk Damgaard, Ueli Nachbur, Monica Yabal, Wendy Wei-Lynn Wong, Berthe Katrine Fiil, Mischa Kastirr, Eva Rieser, James Arthur Rickard, Aleksandra Bankovacki, Christian Peschel, Juergen Ruland, Simon Bekker-Jensen, Niels Mailand, Thomas Kaufmann, Andreas Strasser, Henning Walczak, John Silke, Philipp J Jost, Mads Gyrd-Hansen

Molecular Cell | CELL PRESS | Published : 2012


Awarded by Swiss National Science foundation

Awarded by NHMRC(Canberra)

Awarded by Leukemia and Lymphoma Society

Funding Acknowledgements

We thank Drs. H. Steller, R.A. Flavell, M. Kelliher, C. Borner, C.H. Emmerich, P. Meier, O. Gross, C. Duckett, M. Jaattela, P. Schneider, P. Eitz-Ferrer, G. Nunez, B. Vogelstein, and L.A. O'Reilly for gifts of mice, antibodies, and reagents; Dr. M. Frodin for laboratory space (MG.-H. and R.B.D.); Dr. R. Czajko from the Department of Biochemistry at the Royal Melbourne Hospital for measurements of ALT and AST; and Dr. D. Neuberg from the Department of Biostatistics, School of Public Health and Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard for statistical help. We thank Jan Christian for experimental help and Leigh Zawel and Novartis for LBW-242. This work was supported by a Max-Eder Program grant from the Mildred Scheel-Stiftung/Deutsche Krebshilfe (P.J.J.), a Steno Fellowship from the Danish Council for Independent Research - Natural Sciences (MG.-H.), the Danish Cancer Society (MG.-H.), a fellowship from the Swiss National Science foundation (# PA00P3_126249 to U.N.), the NHMRC (Canberra, program #461221 and fellowship #461299 to AS.), and the Leukemia and Lymphoma Society (SCOR grant #7413 to AS.). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.