Journal article

Linear ubiquitination prevents inflammation and regulates immune signalling

Bjoern Gerlach, Stefanie M Cordier, Anna C Schmukle, Christoph H Emmerich, Eva Rieser, Tobias L Haas, Andrew I Webb, James A Rickard, Holly Anderton, Wendy W-L Wong, Ueli Nachbur, Lahiru Gangoda, Uwe Warnken, Anthony W Purcell, John Silke, Henning Walczak

Nature | NATURE PUBLISHING GROUP | Published : 2011


Awarded by NHMRC

Awarded by Biotechnology and Biological Sciences Research Council

Awarded by Cancer Research UK

Funding Acknowledgements

We thank M. Miasari for developing the cIAP2 antibody, M. Leverkus for advice on skin histology, J. Lokan for advice on liver histology, C. Rappl, N. Barboza, S. Kupka, D. Heinze, J. Zipprich, J. Corbin, S. Wiegelmann and A. Bankovacki for excellent technical assistance, M. Bolognesi and P. Seneci for SM-164, H. Koerner for Tnf<SUP>-/-</SUP> mice, and all past and present members of the Walczak and Silke laboratories for continuous stimulating scientific discussions and support. Research in the Walczak lab is supported by grants from Cancer Research UK, AICR, BBSRC (ERASysBio PLUS), Ovarian Cancer Action and the EU Marie Curie Research Training Network ApopTRAIN. Work in the Silke lab is supported by NHMRC grants 541901, 541902 and 602516. Work in the Purcell lab is supported by the NHMRC (Senior Research Fellowships for A.W.P. and a C.J. Martin Overseas Biomedical Fellowship to A.I.W.), and by grants from the NHMRC and ARC. U.W. is funded by HGF/SBCancer. E.R. and T.L.H. are ApopTRAIN fellows and U.N. is supported by the Schweizer Nationalfonds (SNF).