Journal article
Glycemic memory
A El-Osta
Current Opinion in Lipidology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2012
Abstract
Purpose of review: The mistake of predicting the future is perhaps not tending to repressed or past memories. Hamlet's 17th-Century soliloquy 'the heartache and the thousand natural shocks, that flesh is heir to', (3.1. 7-8) is a tale that looks beyond the present by linking the past with the future. The present article examines the resurgence in the field to understand gene-regulating epigenetic changes conferring glycemic memory. Recent findings: Chromatin modifications are critical in regulating genome structure and function and despite the significant advances of recent years in identifying the enzymes-mediating chemical changes to histone tails and the DNA template, the precise regulati..
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Funding Acknowledgements
The author acknowledges grant and fellowship support from the Juvenile Diabetes Research Foundation International (JDRF), the Diabetes Australia Research Trust (DART), the National Health and Medical Research Council (NHMRC) and the National Heart Foundation of Australia (NHF). AE-O is a recipient of a Senior Research Fellow supported by the NHMRC. Supported in part by the Victorian Government's Operational Infrastructure Support Program.