Journal article

CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche

Stephane Chevrier, Celine Genton, Axel Kallies, Alexander Karnowski, Luc A Otten, Bernard Malissen, Marie Malissen, Marina Botto, Lynn M Corcoran, Stephen L Nutt, Hans Acha-Orbea

Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2009

Abstract

Plasma cells represent the end stage of B-cell development and play a key role in providing an efficient antibody response, but they are also involved in numerous pathologies. Here we show that CD93, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive, memory, and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells, including long-lived plasma cells that showed decreased cell cycle activity, high levels of isotype-switched Ig secretion, and modification of the transcri..

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