Beta-blocker management in high-risk patients presenting for non-cardiac surgery: before and after the POISE Trial
K Leslie, PS Myles, R Halliwell, MJ Paech, TG Short, S Walker
Anaesthesia and Intensive Care | AUSTRALIAN SOC ANAESTHETISTS | Published : 2012
The POISE Trial was a randomised, placebo-controlled, double-blind study of the effectiveness of perioperative beta-blockade in preventing cardiac events including death in 8351 patients. Our hypothesis was that knowledge of the results of the POISE Trial would either increase or decrease the use of effective perioperative beta-blockade, depending on the result. Patients presenting for non-cardiac surgery and at risk of perioperative cardiac events were recruited in two cohorts before and after the release of the POISE Trial results. Effective perioperative beta-blockade was defined as heart rate <65 beats per minute for at least 80% of the perioperative period in patients prescribed beta-bl..View full abstract
Awarded by National Health and Medical Research Council
The POISE study was supported by Project Grants from the National Health and Medical Research Council (282406; 435108).