Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus

DE Ganella; GE Callander; S Ma; CR Bye; AL Gundlach; RAD Bathgate

Journal article

Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus

DE Ganella, GE Callander, S Ma, CR Bye, AL Gundlach, RAD Bathgate

Gene Therapy | NATURE PUBLISHING GROUP | Published : 2013

DOI: 10.1038/gt.2012.83

University of Melbourne Researchers

Chris Bye Author Florey Department of Neuroscience and Mental Health

Andrew Gundlach Author Anatomy and Neuroscience

Ross Bathgate Author Biochemistry and Molecular Biology

Related Projects (2)

Neural Control Of Behavioural State In Health And Disease

Our research aims to describe and understand newly identified nerve pathways or 'networks' in brain that control physiological homeostasis o..

Peptide Neurotransmission In Mental Health And Psychiatric Illness

Our laboratory recently discovered the brain 'transmitter' called 'relaxin-3', and are researching how it affects brain activity and animal ..

Grants

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

We thank Dr Melanie White, Tania Ferraro and Professor Michael McKinley for technical assistance, Dr Changlu Liu (Johnson & Johnson Pharmaceutical Research and Development LLC, San Diego, CA, USA) for provision of the pCMVSportR3/I5 construct, Professor Thomas McCown (University of North Carolina, Chapel Hill, NC, USA) for the kind gift of the TR-FIB-GFP construct, Dr Michael Mathai (Victoria University, Melbourne, VIC, Australia) for the use of the Echo-MRI Body Composition Analyser and Prof. Geoffrey Tregear for his continuing support. This research was supported by National Health and Medical Research Council of Australia Project Grants 509246 (ALG) and 1005988 (ALG, RADB), and by the Victorian Government Operational Infrastructure Support Programme. DEG is the recipient of Commonwealth Australian Postgraduate Award and GEC was the recipient of a University of Melbourne Research Scholarship. SM and ALG and RADB are recipients of NHMRC (Australia) Training and Research Fellowships, respectively.