Journal article
Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain
CM Smith, PJ Shen, A Banerjee, P Bonaventure, S Ma, RAD Bathgate, SW Sutton, AL Gundlach
Journal of Comparative Neurology | Published : 2010
DOI: 10.1002/cne.22442
Abstract
Relaxin-3 (RLN3) and its native receptor, relaxin family peptide 3 receptor (RXFP3), constitute a newly identified neuropeptide system enriched in mammalian brain. The distribution of RLN3/RXFP3 networks in rat brain and recent experimental studies suggest a role for this system in modulation of arousal, stress, metabolism, and cognition. In order to facilitate exploration of the biology of RLN3/RXFP3 in complementary murine models, this study mapped the neuroanatomical distribution of the RLN3/RXFP3 system in mouse brain. Adult, male wildtype and RLN3 knock-out (KO)/LacZ knock-in (KI) mice were used to map the central distribution of RLN3 gene expression and RLN3-like immunoreactivity (-LI)..
View full abstractGrants
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
Grant sponsor: National Health and Medical Research Council of Australia; Grant numbers: 327404 (to C.M.S.), 520299 (to S.M.), 277609, 509246 (to A.L.G.); Grant sponsors: Collaborative Research Agreement with Johnson & Johnson PR&D, LLC, San Diego, CA, Howard Florey Biomedical Foundation USA (to A.L.G.), The University of Melbourne - Melbourne (Postgraduate) Research Scholarship (to A.B.), ANZ Trustees Medical Research & Technology (Victoria, Australia), Perpetual Trustees (to A.L.G., S.M.).This article is dedicated to Prof. Geoffrey Tregear on the occasion of his retirement as Deputy Director of the Howard Florey Institute. The authors thank Tania Ferraro for assistance with the preparation of antisera used in these studies. During these studies C.M.S. was the recipient of an NHMRC (Australia) Dora Lush Biomedical Postgraduate Scholarship.