Dietary omega-3 Deficiency and IOP Insult Are Additive Risk Factors for Ganglion Cell Dysfunction
Christine TO Nguyen, Algis J Vingrys, Bang V Bui
JOURNAL OF GLAUCOMA | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013
AIM: Dietary deficiencies in ω-3 polyunsaturated fatty acids are known to effect retinal function including retinal ganglion cell (RGC) activity, which may have implications for glaucoma. In this study we consider retinal function after dietary manipulation and intraocular pressure (IOP) stress designed to compromise RGCs. METHODS: Sprague-Dawley dams were fed either ω-3 sufficient (ω-3, n=15) or deficient (ω-3, n=16) diets 5 weeks before conception with pups subsequently weaned onto their mothers diets. At 20 weeks of age, acute IOP elevation was induced repeatedly through anterior chamber cannulation to 70 mm Hg for 1 hour on 3 separate occasions separated by 1 week. Electroretinograms wer..View full abstract
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Awarded by NHMRC
Supported by Elizabeth and Vernon Puzey Scholarship (C. T. O. N.), CJ Martin Postdoctoral Fellowship (B. V. B.), NHMRC Project Grants 400127 (B. V. B.) and 350224 (A.J.V.).