Journal article

Use it or lose it: establishment and persistence of T cell memory

Katherine Kedzierska, Sophie A Valkenburg, Peter C Doherty, Miles P Davenport, Vanessa Venturi

FRONTIERS IN IMMUNOLOGY | FRONTIERS RESEARCH FOUNDATION | Published : 2012

Abstract

Pre-existing T cell memory provides substantial protection against viral, bacterial, and parasitic infections. The generation of protective T cell memory constitutes a primary goal for cell-mediated vaccines, thus understanding the mechanistic basis of memory development and maintenance are of major importance. The widely accepted idea that T cell memory pools are directly descended from the effector populations has been challenged by recent reports that provide evidence for the early establishment of T cell memory and suggest that the putative memory precursor T cells do not undergo full expansion to effector status. Moreover, it appears that once the memory T cells are established early in..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NHMRC


Awarded by ARC


Funding Acknowledgements

This work was supported by Australian National Health and Medical Research Council (NHMRC) Project Grants to Katherine Kedzierska (AI1008854), an NHMRC Program Grant (APP567122) to Peter C. Doherty, an ARC Project Grant to Miles P. Davenport and Vanessa Venturi (DP0771340). Katherine Kedzierska is an NHMRC CDF2 Fellow, Sophie A. Valkenburg is an NHMRC Early Career Research Fellow, Vanessa Venturi is an ARC Future Fellow and Miles R Davenport is an NHMRC Senior Research Fellow.