Journal article

In resource-limited settings good early outcomes can be achieved in children using adult fixed-dose combination antiretroviral therapy

Daniel P O'Brien, Delphine Sauvageot, Rony Zachariah, Pierre Humblet

AIDS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2006

Abstract

OBJECTIVES: To (a) determine early treatment outcomes and (b) assess safety in children treated with adult fixed-dose combination (FDC) antiretroviral tablets. SETTING: Sixteen Medecins Sans Frontieres (MSF) HIV programs in eight countries in resource-limited settings (RLS). METHODS: Analysis of routine program data gathered June 2001 to March 2005. RESULTS: A total of 1184 children [median age, 7 years; inter-quartile range (IQR), 4.6-9.3] were treated with antiretroviral therapy (ART) of whom 616(52%) were male. At ART initiation, Centres for Disease Control stages N, A, B and C were 9, 14, 38 and 39%, respectively. Children were followed up for a median period of 6 months (IQR, 2-12 month..

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